About: Propoxyphene     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Propoxyphene
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Propoxyphene
UMLS_CUI
  • C0033493
CAS_Registry
  • 469-62-5
FDA_UNII_Code
  • S2F83W92TK
Contributing_Source
  • FDA
Chemical_Formula
  • C22H29NO2
Legacy_Concept_Name
  • Propoxyphene
CHEBI_ID
  • CHEBI:51173
FULL_SYN
  • PROPOXYPHENEPTFDAS2F83W92TK
  • 4-Dimethylamino-3-methyl-1,2-diphenyl-2-propoxybutaneSNNCI
  • PropoxyphenePTNCI
  • d-PropoxypheneSYNCI
  • SK 65CNNCI
  • AlgafanBRNCI
  • FemadolBRNCI
  • DextropropoxypheneSYNCI
  • AntalvicBRNCI
  • ProxyvonBRNCI
  • ProxagesicBRNCI
DEFINITION
  • The d-isomer of synthetic diphenyl propionate derivative propoxyphene, with narcotic analgesic effect. This agent mimics the effects of the endogenous opiate dextropropoxyphene, by binding to mu receptors located throughout the central nervous system. The binding results in GTP to GDP exchanges on the mu-G-protein complex, by which effector adenylate cyclase is inactivated thereby decreasing intracellular cAMP. This, in turn, inhibits the release of various nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, noradrenaline, vasopressin, and somatostatin. In addition, dextropropoxyphene closes N-type voltage-gated calcium channels and opens calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization, thereby reducing neuronal excitability, which further decreases the perception of pain.NCI
code
  • C61912
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Free_Acid_Or_Base_Form of
is sameAs of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 46 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software