About: Propoxyphene Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Propoxyphene Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Propoxyphene Hydrochloride
UMLS_CUI
  • C0242451
CAS_Registry
  • 1639-60-7
Accepted_Therapeutic_Use_For
  • extravasation resulting from intravenous anthracycline chemotherapy.
FDA_UNII_Code
  • CB2TL9PS0T
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 508976
PDQ_Closed_Trial_Search_ID
  • 508976
Chemical_Formula
  • C22H29NO2.HCl
Legacy_Concept_Name
  • Propoxyphene_Hydrochloride
CHEBI_ID
  • CHEBI:8498
FULL_SYN
  • Dextropropoxyphene HydrochlorideSYNCI
  • alpha-d-Propoxyphene HydrochlorideSYNCI
  • Propoxyphene HydrochloridePTNCI
  • SK 65CNNCI
  • d-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanol Propionate HydrochlorideSNNCI
  • DoleneBRNCI
  • ZideronBRNCI
  • DoraphenSYNCI
  • DolotardBRNCI
  • DoloxeneSYNCI
  • PROPOXYPHENE HYDROCHLORIDEPTFDACB2TL9PS0T
DEFINITION
  • The hydrochloride salt form of the d-isomer of synthetic diphenyl propionate derivative propoxyphene, with narcotic analgesic effect. This agent mimics the effects of the endogenous opiate dextropropoxyphene, by binding to mu receptors located throughout the central nervous system. The binding results in GTP to GDP exchanges on the mu-G-protein complex, by which effector adenylate cyclase is inactivated thereby decreasing intracellular cAMP. This, in turn, inhibits the release of various nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, noradrenaline, vasopressin, and somatostatin. In addition, dextropropoxyphene closes N-type voltage-gated calcium channels and opens calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization, thereby reducing neuronal excitability, which further decreases the perception of pain.NCI
code
  • C29385
sameAs
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