About: Gemifloxacin     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Gemifloxacin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Gemifloxacin
UMLS_CUI
  • C0533545
CAS_Registry
  • 175463-14-6
  • 204519-64-2
FDA_UNII_Code
  • OKR68Y0E4T
Contributing_Source
  • FDA
Chemical_Formula
  • C18H20FN5O4
Legacy_Concept_Name
  • Gemifloxacin
CHEBI_ID
  • CHEBI:101853
FULL_SYN
  • GemifloxacinPTNCI
  • GEMIFLOXACINPTFDAOKR68Y0E4T
DEFINITION
  • A fluoroquinolone antibiotic with antimicrobial property. Gemifloxacin enters bacterial cells by diffusion through integral membrane porin pathway before targeting both DNA gyrase and topoisomerase IV, two enzymes critical for DNA replication and repair. This agent binds to the DNA/DNA-gyrase complex and inhibits the A subunits of the enzyme thereby preventing the bacterial chromosome from rejoining. This interferes with DNA replication and repair processes as well as transcription, and ultimately leads to bacterial cell death. Gemifloxacin targets at both Gram-positive, -negative and atypical human pathogens.NCI
code
  • C61775
sameAs
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