About: Amiloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Amiloride
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Amiloride
PubMedID_Primary_Reference
  • 9563749
UMLS_CUI
  • C0002502
CAS_Registry
  • 2609-46-3
FDA_UNII_Code
  • 7DZO8EB0Z3
Contributing_Source
  • FDA
Chemical_Formula
  • C6H8ClN7O
Legacy_Concept_Name
  • Amiloride
CHEBI_ID
  • CHEBI:2639
FULL_SYN
  • AmiloridePTDCP01107
  • AMILORIDEPTFDA7DZO8EB0Z3
  • AmiloridePTNCI
DEFINITION
  • A synthetic pyrazine derivative with antikaliuretic and diuretic properties. Amiloride inhibits sodium channels located in the distal tubules and collecting ducts of the kidney, thereby preventing the absorption of sodium and increasing its excretion along with water, to produce naturesis. In response to the hypernatremic conditions in the kidney, the plasma membrane becomes hyperpolarized and electrochemical forces are reduced, which then prevents the excretion of potassium and hydrogen into the lumen.NCI
code
  • C61633
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Free_Acid_Or_Base_Form of
is sameAs of
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