About: Amiloride Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Amiloride Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Amiloride Hydrochloride
UMLS_CUI
  • C0026054
CAS_Registry
  • 17440-83-4
FDA_UNII_Code
  • FZJ37245UC
Contributing_Source
  • FDA
Chemical_Formula
  • C6H8ClN7O.ClH.2H2O
Legacy_Concept_Name
  • Amiloride_Hydrochloride
CHEBI_ID
  • CHEBI:2640
FULL_SYN
  • Amiloride HydrochloridePTNCI
  • Pyrazinecarboxamide, N-Amidino-3,5-diamino-6-chloro-, MonohydrochlorideSNNCI
  • AMILORIDE HYDROCHLORIDEPTFDAFZJ37245UC
  • KM87OCNNCI
  • MidamorBRNCI
  • N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide MonohydrochlorideSNNCI
  • CCRIS 5959CNNCI
  • Amiloride HydrochloridePTDCP32076
DEFINITION
  • The hydrochloride salt of amiloride, a synthetic pyrazine derivative with antikaliuretic and diuretic properties. Amiloride inhibits sodium channels located in the distal tubules and collecting ducts of the kidney, thereby preventing the absorption of sodium and increasing its excretion along with water, to produce naturesis. In response to the hypernatremic conditions in the kidney, the plasma membrane becomes hyperpolarized and electrochemical forces are reduced, which then prevents the excretion of potassium and hydrogen into the lumen.NCI
code
  • C47390
sameAs
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