About: Atorvastatin

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Atorvastatin
rdfs:subClassOf	HMG-CoA Reductase Inhibitor nodeID://b647512 nodeID://b647513 nodeID://b647514 nodeID://b647515 nodeID://b647516 nodeID://b647517 nodeID://b647518 nodeID://b647519
Has_Salt_Form	ATORVASTATIN CALCIUM Atorvastatin Sodium
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Atorvastatin
UMLS_CUI	C0286651
CAS_Registry	134523-00-5
FDA_UNII_Code	A0JWA85V8F
Contributing_Source	FDA
ALT_DEFINITION	The active ingredient in a drug used to lower the amount of cholesterol in the blood and to prevent stroke, heart attack, and angina (chest pain). It is also being studied in the prevention and treatment of some types of cancer and other conditions. Atorvastatin blocks an enzyme that helps make cholesterol in the body. It also causes an increase in the breakdown of cholesterol. It is a type of HMG-CoA reductase inhibitor and a type of statin.NCI-GLOSS
Chemical_Formula	C33H35FN2O5
Legacy_Concept_Name	Atorvastatin_Base
CHEBI_ID	CHEBI:39548
FULL_SYN	ATORVASTATINPTFDAA0JWA85V8F AtorvastatinPTNCI atorvastatinPTNCI-GLOSSCDR0000514415 (betaR,deltaR)-2-(p-Fluorophenyl)-beta,delta-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-pyrrole-1-heptanoic AcidSNNCI (betaR,deltaR)-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic AcidSNNCI
DEFINITION	A synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Atorvastatin also increases the number of LDL receptors on hepatic cell surfaces to enhance uptake and catabolism of LDL and reduces LDL production and the number of LDL particles. This agent lowers plasma cholesterol and lipoprotein levels and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)NCI
code	C61527
sameAs	ATORVASTATIN
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0179294
is Has_Free_Acid_Or_Base_Form of	ATORVASTATIN CALCIUM Atorvastatin Sodium
is sameAs of	ATORVASTATIN ATORVASTATIN

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