About: Atorvastatin Sodium     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Atorvastatin Sodium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Atorvastatin Sodium
UMLS_CUI
  • C2698196
CAS_Registry
  • 134523-01-6
FDA_UNII_Code
  • DN43058TIV
Contributing_Source
  • FDA
Chemical_Formula
  • C33H34FN2O5.Na
Legacy_Concept_Name
  • Atorvastatin_Sodium
FULL_SYN
  • Atorvastatin SodiumPTNCI
  • ATORVASTATIN SODIUMPTFDADN43058TIV
DEFINITION
  • The sodium salt of atorvastatin, a synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent increases the number of LDL receptors on hepatic cell surfaces, enhancing the uptake and catabolism of LDL and reducing LDL production and the number of LDL particles, and lowers plasma cholesterol and lipoprotein levels. Like other statins, atorvastatin may also display direct antineoplastic activity, possibly by inhibiting farnesylation and geranylgeranylation of proteins such as small GTP-binding proteins, which may result in the arrest of cells in the G1 phase of the cell cycle. This agent may also sensitize tumor cells to cyctostatic drugs, possibly through the mTOR-dependent inhibition of Akt phosphorylation.NCI
code
  • C78676
is Has_Salt_Form of
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