About: Nitric Oxide-Releasing Acetylsalicylic Acid Derivative     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Nitric Oxide-Releasing Acetylsalicylic Acid Derivative
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Nitric Oxide-Releasing Acetylsalicylic Acid Derivative
UMLS_CUI
  • C0531264
ALT_DEFINITION
  • A substance being studied in the prevention of colorectal cancer. It is a form of aspirin that gives off nitric oxide gas and is less irritating to the lining of the stomach than plain aspirin. It is a type of nonsteroidal anti-inflammatory drug (NSAID).NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 486415
PDQ_Closed_Trial_Search_ID
  • 486415
Legacy_Concept_Name
  • Nitric_Oxide-Releasing_Acetylsalicylic_Acid_Derivative
FULL_SYN
  • NitroaspirinSYNCI
  • Nitric Oxide-Releasing Acetylsalicylic Acid DerivativePTNCI
  • NCX 4016PTNCI-GLOSSCDR0000523326
  • NCX 4016ABNCI
  • NCX 4016PTDCP20408
  • Nitric Oxide-Releasing Aspirin DerivativeSYNCI
  • nitric oxide-releasing acetylsalicylic acid derivativePTNCI-GLOSSCDR0000488417
  • Benzoic Acid, 2-(Acetyl-oxy)-3-[(nitrooxy)methyl]phenyl EsterSNNCI
DEFINITION
  • A nitric oxide (NO) donating derivative of acetylsalicylic acid with anti-inflammatory, analgesic, antipyretic, antithrombotic, gastroprotective and potential antitumor activities. The acetylsalicylic acid derivative moiety of this agent inhibits the activities of cyclooxygenase (COX) I and II, preventing the formation of prostaglandins and thromboxanes. A reduction in prostaglandin synthesis accounts for this agent's anti-inflammatory, anti-pyretic and analgesic activities; a reduction in thromboxane A2 synthesis results in an irreversible inhibition of platelet aggregation. NO donation by this agent, after cleavage from the acetylsalicylic acid derivative in vivo, may protect the gastric mucosa against the damaging effects of the aspirin derivative by modulating prostaglandins. In tumor cells, the NO donating moiety may block the cell cycle in the G1 and G2 phases and may induce apoptosis through caspase-mediated mechanisms.NCI
code
  • C61499
http://linked.open...y/mesh/hasConcept
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