About: Amonafide L-Malate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Amonafide L-Malate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Amonafide L-Malate
UMLS_CUI
  • C1879697
CAS_Registry
  • 618863-54-0
Accepted_Therapeutic_Use_For
  • Treatment of secondary acute myeloid leukemia
FDA_UNII_Code
  • LI06Q37TEG
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 485171
PDQ_Closed_Trial_Search_ID
  • 485171
Chemical_Formula
  • C16H17N3O2.C4H6O5
Legacy_Concept_Name
  • Amonafide_L-Malate
FULL_SYN
  • Butanedioic Acid, 2-hydroxy-, (2S)-, compd. with 5-amino-2-(2-(dimethylamino)ethyl-1h-benz[de]isoquinoline-1,3(2h)-dione (1:1)SYNCI
  • 5-amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione (2S)-2-ydroxybutanedioateSNNCI
  • AS1413CNNCI
  • XAN-02CNNCI
  • Amonafide L-MalatePTNCI
  • AMONAFIDE L-MALATEPTFDALI06Q37TEG
  • XanafideBRNCI
DEFINITION
  • The malate salt of amonafide, an imide derivative of naphthalic acid, with potential antineoplastic activity. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in DNA double-strand breaks (DSB) and inhibition of DNA replication and RNA synthesis.NCI
code
  • C61306
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
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