About: Bosutinib

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Bosutinib
rdfs:subClassOf	Tyrosine Kinase Inhibitor nodeID://b651496 nodeID://b651497 nodeID://b651498 nodeID://b651499 nodeID://b651500
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Bosutinib
UMLS_CUI	C1831731
CAS_Registry	380843-75-4
In_Clinical_Trial_For	Philadelphia chromosome positive leukemias; breast cancer; advanced malignant solid tumors
FDA_UNII_Code	5018V4AEZ0
Contributing_Source	FDA
PDQ_Open_Trial_Search_ID	467222
PDQ_Closed_Trial_Search_ID	467222
Chemical_Formula	C26H29Cl2N5O3
Legacy_Concept_Name	Bosutinib
CHEBI_ID	CHEBI:39112
FULL_SYN	4-Anilino-3-quinolinecarbonitrileSNNCI 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrileSNNCI BOSUTINIBPTFDA5018V4AEZ0 SKI 606CNNCI SKI-606CNNCI SKI-606PTDCP32145 BosulifBRNCI 4-Anilinobenzo(g)quinoline-3-carbonitrileSNNCI BosutinibPTNCI
DEFINITION	A synthetic quinolone derivative and dual kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity. Unlike imatinib, bosutinib inhibits the autophosphorylation of both Abl and Src kinases, resulting in inhibition of cell growth and apoptosis. Because of the dual mechanism of action, this agent may have activity in resistant CML disease, other myeloid malignancies and solid tumors. Abl kinase is upregulated in the presence of the abnormal Bcr-abl fusion protein which is commonly associated with chronic myeloid leukemia (CML). Overexpression of specific Src kinases is also associated with the imatinib-resistant CML phenotype.NCI
code	C60809
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0446825
is sameAs of	BOSUTINIB

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