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AttributesValues
rdf:type
rdfs:label
  • Ganciclovir
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Ganciclovir
NSC_Code
  • 716361
UMLS_CUI
  • C0017066
CAS_Registry
  • 82410-32-0
Accepted_Therapeutic_Use_For
  • Cytomegalovirus (CMV) Infections in Immunocompromised Patients.
In_Clinical_Trial_For
  • In Patients with Epstein Barr Virus-Induced Malignancies or Lymphoproliferative Disorders; In Gene Therapy; Cutaneous or Subcutaneous Metastatic Malignant Melanoma and Primary Brain Tumors.
FDA_UNII_Code
  • P9G3CKZ4P5
Contributing_Source
  • FDA
ALT_DEFINITION
  • An antiviral agent used to prevent or treat cytomegalovirus infections that may occur when the body's immune system is suppressed. In gene therapy, ganciclovir is used with an altered herpes simplex virus-1 gene to kill advanced melanoma cells and brain tumor cells.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 40565
PDQ_Closed_Trial_Search_ID
  • 40565
Chemical_Formula
  • C9H13N5O4
Legacy_Concept_Name
  • Ganciclovir
CHEBI_ID
  • CHEBI:465284
FULL_SYN
  • 2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-oneSNNCI
  • GanciclovirPTNCI
  • 2'-Nor-2'-deoxyguanosineSNNCI
  • ganciclovirPTNCI-GLOSSCDR0000045303
  • GCVABNCI
  • DHPGABNCI
  • 2'NDGABNCI
  • NordeoxyguanosineSYNCI
  • VirganFBNCI
  • CymevanFBNCI
  • GANCICLOVIRPTFDAP9G3CKZ4P5
  • NordeoxyguanosineSYDTPNSC0716361
  • 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanineSNNCI
DEFINITION
  • A synthetic guanine derivative with antiviral activity. As the active metabolite of ganciclovir, ganciclovir-5-triphosphate (ganciclovir-TP) appears to inhibit viral DNA synthesis by competitive inhibition of viral DNA polymerases and incorporation into viral DNA, resulting in eventual termination of viral DNA elongation.NCI
code
  • C517
sameAs
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