About: Ganciclovir Sodium

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Ganciclovir Sodium
rdfs:subClassOf	Purine Antagonist ANTIVIRALS DNA Polymerase Inhibitors
Has_Free_Acid_Or_Base_Form	GANCICLOVIR
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name	Ganciclovir Sodium
NSC_Code	716361
UMLS_CUI	C0282399
CAS_Registry	107910-75-8
FDA_UNII_Code	02L083W284
Contributing_Source	FDA
Chemical_Formula	C9H12N5O4.Na
Legacy_Concept_Name	Ganciclovir_Sodium
FULL_SYN	DHPG sodiumSYNCI Cytovene-IVBRNCI RS-21592 SodiumCNNCI BW-759CNNCI CytoveneSYDTPNSC0716361 BW-759UCNNCI Ganciclovir SodiumPTNCI GANCICLOVIR SODIUMPTFDA02L083W284 BIOLF-62CNNCI GCV SodiumSYDTPNSC0716361 DenosineFBNCI CymeveneFBNCI DHPG SodiumSYDTPNSC0716361 9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine, Monosodium SaltSNNCI GCV sodiumSYNCI Ganciclovir sodiumSYDTPNSC0716361
DEFINITION	The sodium salt form of ganciclovir, a synthetic, antiviral, purine nucleoside analog with antiviral activity, especially against cytomegalovirus (CMV). Ganciclovir sodium is a prodrug that is phosphorylated and subsequently converted into its triphosphate form, the active metabolite ganciclovir-5-triphosphate (ganciclovir-TP), in the infected cells by cellular kinases. Ganciclovir-TP competes as a substrate with nucleotide triphosphates for viral DNA polymerase. Once it gets incorporated into DNA strand, it prevents further polymerization of DNA, thereby interfering with viral DNA replication.NCI
code	C1588
sameAs	GANCICLOVIR (AS SODIUM) GANCICLOVIR (AS SODIUM)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0024169
is Has_Salt_Form of	GANCICLOVIR
is sameAs of	GANCICLOVIR (AS SODIUM) GANCICLOVIR (AS SODIUM) GANCICLOVIR (AS SODIUM)

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