About: Bardoxolone     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Bardoxolone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Bardoxolone
NSC_Code
  • 711193
UMLS_CUI
  • C0762434
CAS_Registry
  • 218600-44-3
Accepted_Therapeutic_Use_For
  • Antineoplastic and anti-inflammatory
FDA_UNII_Code
  • 7HT68L8941
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of some types of cancer. CDDO may block enzymes involved in inflammation and cancer growth. It is a type of antineoplastic plant product.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 453589
PDQ_Closed_Trial_Search_ID
  • 453589
Chemical_Formula
  • C31H41NO4
Legacy_Concept_Name
  • CDDO
FULL_SYN
  • 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic AcidSNNCI
  • BardoxolonePTNCI
  • CDDOPTNCI-GLOSSCDR0000518302
  • 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic AcidPTDCP31757
  • CDDOABNCI
  • RTA 401CNNCI
  • Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-SNNCI
  • BARDOXOLONEPTFDA7HT68L8941
DEFINITION
  • A synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities. Bardoxolone blocks the synthesis of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), two enzymes involved in inflammation and carcinogenesis. This agent also inhibits the interleukin-1 (IL-1)-induced expression of the pro-inflammatory proteins matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-13 (MMP-13) and the expression of Bcl-3; Bcl-3 is an IL-1-responsive gene that preferentially contributes to MMP-1 gene expression.NCI
code
  • C48382
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