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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Alteplase
rdfs:subClassOf
Concept_In_Subset
Is_Related_To_Endogenous_Product
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Alteplase
UMLS_CUI
  • C0032143
CAS_Registry
  • 105857-23-6
FDA_UNII_Code
  • 1RXS4UE564
Contributing_Source
  • FDA
ALT_DEFINITION
  • A form of tissue plasminogen activator that is made in the laboratory. It helps dissolve blood clots and is used to treat heart attacks, strokes, and clots in the lungs. It is also being studied in the treatment of cancer. It is a type of systemic thrombolytic agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42033
PDQ_Closed_Trial_Search_ID
  • 42033
Legacy_Concept_Name
  • Recombinant_Tissue_Plasminogen_Activator
FULL_SYN
  • r-tPASYNCI-GLOSSCDR0000373954
  • Plasminogen Activator (Human Tissue-Type Protein Moiety)SYNCI
  • rt-PAABNCI
  • ALTEPLASEPTFDA1RXS4UE564
  • recombinant tissue plasminogen activatorSYNCI-GLOSSCDR0000377722
  • ActivaseSYNCI-GLOSSCDR0000377724
  • ActivaseBRNCI
  • Recombinant Tissue Plasminogen ActivatorSYNCI
  • AlteplasePTNCI
  • AlteplasePTNCI-GLOSSCDR0000377725
DEFINITION
  • A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, alteplase increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism.NCI
code
  • C39607
sameAs
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