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AttributesValues
rdf:type
rdfs:label
  • Tissue Plasminogen Activator
equivalentClass
OMIM_Number
  • 173370
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • Tissue Plasminogen Activator
UMLS_CUI
  • C0256103
ALT_DEFINITION
  • An enzyme made in the body that helps dissolve blood clots. A form of this enzyme is made in the laboratory to treat heart attacks, strokes, and clots in the lungs. It is also being studied in the treatment of cancer. Tissue plasminogen activator is a type of systemic thrombolytic agent.NCI-GLOSS
Legacy_Concept_Name
  • Tissue_Plasminogen_Activator
FULL_SYN
  • TPASYNCI
  • PLATSYNCI
  • EC 3.4.21.68SYNCI
  • tPAPTNCI-GLOSSCDR0000377721
  • Tissue-Type Plasminogen ActivatorSYNCI
  • T-Plasminogen ActivatorSYNCI
  • t-PASYNCI
  • Tissue Plasminogen ActivatorPTNCI
  • tissue plasminogen activatorPTNCI-GLOSSCDR0000377718
Swiss_Prot
  • P00750
DEFINITION
  • Tissue Plasminogen Activator isoforms 1 (562-aa, 63-kD), 2 (291-aa, frameshifted with distinct C-terminus), and 3 (516-aa, deleted Ex4) are encoded by human PLAT Gene (Peptidase S1 Family). EGF-like, fibronectin I, and kringle domains mediate fibrin, LRP1, annexin II, and cytokeratin 8 binding. TPA also binds to laminin, fibronectin, and mannose receptor. Inhibited by PAI-1, serine protease TPA is widely expressed as an active single chain, then secreted, and cleaved by plasmin, tissue kallikrein, or factor XA to a fully active disulfide linked A/B-protein; N-heavy chain and C-light chain. Important in cell migration and tissue remodeling, TPA activates (increased by fibrin or heparin) plasminogen to fibrinolytic plasmin conversion by hydrolyzing a specific Arg-Val bond. Altered activity causes hyper- or hypofibrinolysis. (from LocusLink, Swiss-Prot, OMIM, and NCI)NCI
  • A secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. (from LocusLink)NCI
  • Tissue plasminogen activator (PLAT) is a serine protease that activates the proenzyme plasminogen to plasmin, which in turn is responsible for fibrinolytic activity. PLAT is synthesized in vascular endothelial cells as a single polypeptide chain. Proteolytic cleavage of the single chain protein at a centrally located arginine-isoleucine bond by plasmin gives rise to a 2-chain disulfide-linked form, composed of the N-terminally derived heavy chain and the C-terminal light chain.NCI
code
  • C16995
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