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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pertuzumab
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • Pertuzumab
NSC_Code
  • 740102
UMLS_CUI
  • C1328025
CAS_Registry
  • 380610-27-5
In_Clinical_Trial_For
  • Ovarian epithelial, peritoneal, or fallopian tube cancer; solid tumor cancers
FDA_UNII_Code
  • K16AIQ8CTM
Contributing_Source
  • FDA
ALT_DEFINITION
  • A monoclonal antibody that is being studied in the treatment of cancer. Monoclonal antibodies are produced in the laboratory and can locate and bind to cancer cells.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 322808
PDQ_Closed_Trial_Search_ID
  • 322808
Legacy_Concept_Name
  • Pertuzumab
FULL_SYN
  • 2C4 AntibodySYNCI
  • 2C4SYNCI
  • MoAb 2C4ABNCI
  • PertuzumabPTNCI
  • pertuzumabPTNCI-GLOSSCDR0000340934
  • Monoclonal Antibody 2C4SYNCI
  • PerjetaBRNCI
  • PERTUZUMABPTFDAK16AIQ8CTM
  • rhuMAb2C4SYNCI
DEFINITION
  • A humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein dimerization prevents the activation of HER signaling pathways, resulting in tumor cell apoptosis. (NCI04)NCI
code
  • C38692
sameAs
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