About: Pertuzumab

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Pertuzumab
rdfs:subClassOf	Antibodies, Monoclonal
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Immunologic Factor
Preferred_Name	Pertuzumab
NSC_Code	740102
UMLS_CUI	C1328025
CAS_Registry	380610-27-5
In_Clinical_Trial_For	Ovarian epithelial, peritoneal, or fallopian tube cancer; solid tumor cancers
FDA_UNII_Code	K16AIQ8CTM
Contributing_Source	FDA
ALT_DEFINITION	A monoclonal antibody that is being studied in the treatment of cancer. Monoclonal antibodies are produced in the laboratory and can locate and bind to cancer cells.NCI-GLOSS
PDQ_Open_Trial_Search_ID	322808
PDQ_Closed_Trial_Search_ID	322808
Legacy_Concept_Name	Pertuzumab
FULL_SYN	2C4 AntibodySYNCI 2C4SYNCI MoAb 2C4ABNCI PertuzumabPTNCI pertuzumabPTNCI-GLOSSCDR0000340934 Monoclonal Antibody 2C4SYNCI PerjetaBRNCI PERTUZUMABPTFDAK16AIQ8CTM rhuMAb2C4SYNCI
DEFINITION	A humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein dimerization prevents the activation of HER signaling pathways, resulting in tumor cell apoptosis. (NCI04)NCI
code	C38692
sameAs	PERTUZUMAB
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0466011
is sameAs of	PERTUZUMAB PERTUZUMAB

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