About: Anti-MART-1 TCR Retroviral Vector-Transduced Autologous TIL     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Anti-MART-1 TCR Retroviral Vector-Transduced Autologous TIL
rdfs:subClassOf
Has_Target
Semantic_Type
  • Cell
  • Pharmacologic Substance
Preferred_Name
  • Anti-MART-1 TCR Retroviral Vector-Transduced Autologous TIL
NSC_Code
  • 729278
UMLS_CUI
  • C1510930
Legacy_Concept_Name
  • Anti-MART-1_TCR_Retroviral_Vector-Transduced_Autologous_TIL
FULL_SYN
  • Anti-MART-1 TCR Retroviral Vector-Transduced Autologous TILPTNCI
  • MSGV1AIB (Anti-MART-1 TCR) Retroviral Vector-Transduced Autologous TILSYNCI
DEFINITION
  • Human tumor infiltrating lymphocytes (TIL) isolated from a melanoma patient and were engineered to react with the melanoma antigen MART-1 (Melanoma Antigen Recognized by T cells, also called Melan-A). These TILs are transfected with a retroviral vector encoding anti-MART-1 specific T-cell receptors, grown in culture, and then transferred back to the patient. These genetically modified TIL may recognize and halt the growth of MART-1-expressing melanoma cells.NCI
code
  • C38137
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