About: Ispinesib     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ispinesib
rdfs:subClassOf
Has_Salt_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Ispinesib
NSC_Code
  • 727990
UMLS_CUI
  • C1527260
CAS_Registry
  • 336113-53-2
FDA_UNII_Code
  • BKT5F9C2NI
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. Ispinesib blocks a protein that tumor cells need to divide. It is a type of mitotic inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 391236
PDQ_Closed_Trial_Search_ID
  • 391236
Chemical_Formula
  • C30H33ClN4O2
Legacy_Concept_Name
  • SB-715992
FULL_SYN
  • ISPINESIBPTFDABKT5F9C2NI
  • SB-715992PTNCI-GLOSSCDR0000413793
  • CK0238273CNNCI
  • SB-715992CNNCI
  • IspinesibPTNCI
  • SB-715992PTDCP50670
  • ispinesibPTNCI-GLOSSCDR0000535569
DEFINITION
  • A synthetic small molecule, derived from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein, kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that are actively dividing. Because KSP is not involved in nonmitotic processes, such as neuronal transport, ispinesib may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents.NCI
code
  • C38131
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