About: Sulindac Sulfide     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Sulindac Sulfide
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Sulindac Sulfide
UMLS_CUI
  • C0075615
CAS_Registry
  • 49627-27-2
Legacy_Concept_Name
  • Sulindac_Sulfide
FULL_SYN
  • (1Z)-5-Fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic AcidSNNCI
  • Sulindac SulfidePTNCI
  • Sulindac SulfidePTDCP09395
DEFINITION
  • The active metabolite of sulindac, a sulfinylindene derivative with anti-inflammatory, analgesic and antipyretic properties. Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) which inhibits cyclooxygenase (COX-1 and-2)-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. This agent may possess chemopreventive activity against colorectal tumors through a mechanism that involves the induction of apoptosis. The sulfide metabolite is excreted in the bile and reabsorbed from the intestine, thereby helping to maintain constant blood levels and reduce gastrointestinal side effects. (NCI04)NCI
code
  • C29854
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