About: Sumatriptan Succinate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Sumatriptan Succinate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Sumatriptan Succinate
UMLS_CUI
  • C0206599
CAS_Registry
  • 103628-48-4
FDA_UNII_Code
  • J8BDZ68989
Contributing_Source
  • FDA
Chemical_Formula
  • C14H21N3O2S.C4H6O4
Legacy_Concept_Name
  • Sumatriptan_Succinate
CHEBI_ID
  • CHEBI:64359
FULL_SYN
  • SUMATRIPTAN SUCCINATEPTFDAJ8BDZ68989
  • ImitrexBRNCI
  • Sumatriptan SuccinatePTNCI
DEFINITION
  • The succinate salt form of sumatriptan, a member of the triptan class of compounds with anti-migraine property. Sumatriptan succinate selectively binds to and activates serotonin 5-HT1 receptors. This results in constriction of meningeal, dural, cerebral or pial blood vessels via stimulation of the 5-HT1B receptors, thereby reducing the vascular pulsation and may provide relief in migraine headaches. Furthermore, agonistic action of this agent through presynaptic stimulation of 5-HT1D and/or 5-HT1F receptors prevents release of vasoactive and pro-inflammatory neuropeptide (calcitonin gene-related peptide), thereby may also relieve migraine headaches. In addition, central inhibition of pain transmission via the inhibition of trigeminal neurons in the brain stems and upper spinal cord mediated by 5-HT1B, 5-HT1D or 5-HT 1F receptors also aides in the alleviation of migraine pain.NCI
code
  • C29470
sameAs
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