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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Labetalol
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Labetalol
UMLS_CUI
  • C0022860
CAS_Registry
  • 36894-69-6
FDA_UNII_Code
  • R5H8897N95
Contributing_Source
  • FDA
Chemical_Formula
  • C19H24N2O3
Legacy_Concept_Name
  • Labetalol
CHEBI_ID
  • CHEBI:6343
FULL_SYN
  • LabetalolPTDCP30283
  • LABETALOLPTFDAR5H8897N95
  • LabetalolPTNCI
DEFINITION
  • A third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects.NCI
code
  • C29146
sameAs
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