About: Labetalol Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Labetalol Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Labetalol Hydrochloride
NSC_Code
  • 290312
UMLS_CUI
  • C0699440
CAS_Registry
  • 32780-64-6
FDA_UNII_Code
  • 1GEV3BAW9J
Contributing_Source
  • FDA
Chemical_Formula
  • C19H24N2O3.HCl
Legacy_Concept_Name
  • Labetalol_Hydrochloride
FULL_SYN
  • Labetalol HydrochloridePTNCI
  • LABETALOL HYDROCHLORIDEPTFDA1GEV3BAW9J
  • TrandateBRNCI
  • NormodyneBRNCI
  • Labetalol HydrochloridePTDCP30258
DEFINITION
  • The hydrochloride form of labetalol, a third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects.NCI
code
  • C63578
sameAs
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