About: Demeclocycline Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Demeclocycline Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Demeclocycline Hydrochloride
UMLS_CUI
  • C0701198
CAS_Registry
  • 64-73-3
FDA_UNII_Code
  • 29O079NTYT
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied as a way to detect bone growth in patients receiving bisphosphonates (a type of drug used to treat bone pain caused by some types of cancer) for breast cancer. It binds to newly formed bone. A biopsy is done and bone growth is measured using a special microscope. Declomycin is a type of tetracycline antibiotic and a type of bone-labeling agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 659335
PDQ_Closed_Trial_Search_ID
  • 659335
Chemical_Formula
  • C21H21ClN2O8.HCl
Legacy_Concept_Name
  • Demeclocycline_Hydrochloride
CHEBI_ID
  • CHEBI:59725
FULL_SYN
  • 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide MonohydrochlorideSNNCI
  • DEMECLOCYCLINE HYDROCHLORIDEPTFDA29O079NTYT
  • DeclomycinPTNCI-GLOSSCDR0000644736
  • Demeclocycline HydrochloridePTNCI
  • demeclocycline hydrochloridePTNCI-GLOSSCDR0000644735
  • DeclomycinBRNCI
DEFINITION
  • The hydrochloride salt of demeclocycline, a broad-spectrum, tetracycline derivative exhibiting antimicrobial, aquaretic and chelating activities. In bacteria, demeclocycline binds reversibly to the 30S ribosomal subunit and blocks the binding of aminoacyl-tRNA to the A-site of the mRNA-ribosome complex, resulting in the inhibition of protein synthesis and bacterial cell death. In mammals, this agent interferes with the action of antidiuretic hormone (ADH) at the level of the renal collecting tubule, resulting in aquaresis. In addition, demeclocycline, which like other tetracyclines chelates calcium in bone and exhibits a yellow fluorescence under ultraviolet (UV) light, may be used as a fluorescent bone-labeling agent in bone histomorphometry.NCI
code
  • C28975
sameAs
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