About: Cefuroxime Axetil

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Cefuroxime Axetil
rdfs:subClassOf	Cephalosporin Antibacterial
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Antibiotic Organic Chemical
Preferred_Name	Cefuroxime Axetil
UMLS_CUI	C0055015
CAS_Registry	64544-07-6
FDA_UNII_Code	Z49QDT0J8Z
Contributing_Source	FDA
Chemical_Formula	C20H22N4O10S
Legacy_Concept_Name	Cefurexine_Axetil
FULL_SYN	Cefuroxime AxetilPTNCI CEFUROXIME AXETILPTFDAZ49QDT0J8Z
DEFINITION	A second generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefuroxime's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefuroxime inhibits bacterial septum and cell wall synthesis formation.NCI
code	C28918
sameAs	CEFUROXIME AXETIL CEFUROXIME AXETIL
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0121148
is sameAs of	CEFUROXIME AXETIL CEFUROXIME AXETIL CEFUROXIME AXETIL

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