About: PR7V10 (ras-12 Ala) Peptide     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • PR7V10 (ras-12 Ala) Peptide
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • PR7V10 (ras-12 Ala) Peptide
NSC_Code
  • 706864
UMLS_CUI
  • C1518812
Legacy_Concept_Name
  • PR7v10_ras_12Ala_Peptide
FULL_SYN
  • PR7V10 (ras-12 Ala) PeptidePTNCI
DEFINITION
  • A natural or synthetic peptide derived from the Ras protein with potential use in cancer immunotherapy. Ras protein regulates a number of signalling molecules by translocating them to the plasma membrane for activation and may serve as a branchpoint in signal transduction because it orchestrates the activity of multiple signalling pathways to regulate diverse cellular functions. Ras-12 Ala is a mutated form of the wild-type Ras protein in which the amino acid glycine at codon 12 is replaced with alanine. Vaccination with mutated Ras proteins or peptides may stimulate cytotoxic host immune responses to tumor cells that express similarly mutated Ras proteins. (NCI04)NCI
code
  • C2796
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