About: Donepezil Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Donepezil Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Donepezil Hydrochloride
UMLS_CUI
  • C0771848
CAS_Registry
  • 120011-70-3
  • 142057-77-0
Accepted_Therapeutic_Use_For
  • Alzheimers disease and opioid-induced sedation.
In_Clinical_Trial_For
  • prevention of cognitive dysfunction following cancer treatment that included prophylactic cranial irradiation in patients with small cell lung cancer.
  • Prevention of Cognitive Dysfunction Following Cancer Treatment that included Prophylactic Cranial Irradiation in Patients with Small Cell Lung Cancer.
FDA_UNII_Code
  • 3O2T2PJ89D
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 38109
PDQ_Closed_Trial_Search_ID
  • 38109
Chemical_Formula
  • C24H29NO3.HCl
Legacy_Concept_Name
  • Donepezil
CHEBI_ID
  • CHEBI:4696
FULL_SYN
  • Donepezil HydrochloridePTNCI
  • 1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine HydrochlorideSNNCI
  • DONEPEZIL HYDROCHLORIDEPTFDA3O2T2PJ89D
  • E-2020CNNCI
  • AriceptBRNCI
DEFINITION
  • The hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil reversibly inhibits acetylcholinesterase, thereby blocking the hydrolysis of the neurotransmitter acetylcholine and, consequently, increasing its activity. This agent may improve neurocognitive function in Alzheimer's disease, reduce sedation associated with opioid treatment of cancer pain, and improve neurocognitive function in patients who have received radiation therapy for primary brain tumors or brain metastases.NCI
code
  • C2603
sameAs
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is someValuesFrom of
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