About: LMB-9 Immunotoxin     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • LMB-9 Immunotoxin
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • LMB-9 Immunotoxin
NSC_Code
  • 691236
UMLS_CUI
  • C0678023
In_Clinical_Trial_For
  • Advanced colon, esophageal, pancreatic, rectal, and stomach cancer overexpressing Lewis Y antigen
ALT_DEFINITION
  • A toxic substance linked to an antibody that attaches to tumor cells and kills them.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43018
PDQ_Closed_Trial_Search_ID
  • 43018
Legacy_Concept_Name
  • LMB-9_Immunotoxin
FULL_SYN
  • LMB-9 immunotoxinPTNCI-GLOSSCDR0000045968
  • B3 (dsFv)-PE38SYNCI
  • LMB-9SYNCI
  • LMB-9 ImmunotoxinPTNCI
  • Immunotoxin LMB-9SYNCI
DEFINITION
  • A recombinant disulfide stabilized anti-Lewis Y IgG immunotoxin containing a 38 KD toxic element derived from the Pseudomonas aeruginosa exotoxin A and a monoclonal antibody fragment, designed to target adenocarcinomas expressing Lewis Y. LMB-9 immunotoxin attaches to tumor cells, facilitating he entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis.NCI
code
  • C2472
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