About: Duocarmycin Antineoplastic Antibiotic     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Duocarmycin Antineoplastic Antibiotic
rdfs:subClassOf
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • Duocarmycin Antineoplastic Antibiotic
UMLS_CUI
  • C1512091
Legacy_Concept_Name
  • Duocarmycin_Antibiotic
FULL_SYN
  • DuocarmycinsSYNCI
  • Duocarmycin Antineoplastic AntibioticPTNCI
DEFINITION
  • A spirocyclopropylhexadienone-containing antineoplastic antibiotic isolated from Streptomyces bacterial species or derived synthetically. Duocarmycin antibiotics alkylate DNA by binding to adenine-thymine (A-T)- rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.NCI
code
  • C2156
is rdf:first of
is rdfs:subClassOf of
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