About: Pibrozelesin

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Pibrozelesin
rdfs:subClassOf	Duocarmycin Antineoplastic Antibiotic
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Antibiotic Organic Chemical Pharmacologic Substance
Preferred_Name	Pibrozelesin
UMLS_CUI	C0254093
CAS_Registry	154889-68-6
FDA_UNII_Code	IHK933KCIC
Contributing_Source	FDA
ALT_DEFINITION	A semisynthetic anticancer drug that is a type of antitumor antibiotic.NCI-GLOSS
PDQ_Open_Trial_Search_ID	42429
PDQ_Closed_Trial_Search_ID	42429
Chemical_Formula	C32H36BrN5O8
Legacy_Concept_Name	KW_2189
FULL_SYN	PIBROZELESINPTFDAIHK933KCIC PibrozelesinPTNCI KW2189PTNCI-GLOSSCDR0000046042 Benzo(1,2-b:4,3-b')dipyrrole-1-carboxylic Acid, 8-(bromomethyl)-3,6,7,8-tetrahydro-2-methy-4-(((4-methyl-1-piperazinyl)carbonyl)oxy)-6-((5,6,7,-trimethoxy-1H-indol-2-yl)carbonyl)-, Methyl Ester (S)SNNCI KW 2189CNNCI KW-2189CNNCI Duocamycin B2 AnalogSYNCI
DEFINITION	A semisynthetic water-soluble derivative of the antineoplastic antibiotic duocarmycin B2. Activated by carboxyl esterase, pibrozelesin alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.NCI
code	C1542
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0230329

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