About: T-Cell Differentiation in the Thymus     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • T-Cell Differentiation in the Thymus
rdfs:subClassOf
Semantic_Type
  • Cell Function
Preferred_Name
  • T-Cell Differentiation in the Thymus
UMLS_CUI
  • C1515432
Legacy_Concept_Name
  • Thymocyte_Development
FULL_SYN
  • T-Cell Differentiation in the ThymusPTNCI
  • Thymocyte DevelopmentSYNCI
DEFINITION
  • progression of T cell precursors in the thymus through many stages of maturation. These stages include regulated expression of the alpha and beta (or gamma and delta) chains of the T cell receptor, expression of both CD4 and CD8 molecules (double positive stage), down regulation to a single positive stage (CD4 or CD8), as well as allowing those thymocytes to die which are unable to bind to self MHC molecules (death by neglect), selecting those thymocytes with T Cell Receptors that are able to bind to self MHC molecules with moderate affinity (positive selection), and deleting those thymocytes having T Cell Receptors that bind with high affinity to self MHC (negative selection), before allowing mature T cells to emigrate to the periphery.NCI
code
  • C19317
is rdfs:subClassOf of
is someValuesFrom of
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