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AttributesValues
rdf:type
rdfs:label
  • T-Cell Differentiation
rdfs:subClassOf
Semantic_Type
  • Cell Function
Preferred_Name
  • T-Cell Differentiation
UMLS_CUI
  • C1155013
Legacy_Concept_Name
  • T-Cell_Development
FULL_SYN
  • T-Cell DifferentiationPTNCI
  • T-Lymphocyte DevelopmentSYNCI
  • T-Cell OntogenySYNCI
  • T-Cell DevelopmentSYNCI
DEFINITION
  • Development of bone marrow-derived stem cells in the thymus through stages of positive selection under the influence of epithelial cells in the thymic cortex and negative selection under the influence of bone marrow-derived dendritic cells at the corticomedullary junction. Thymic T cell precursors (thymocytes) progress through phases expressing both CD4 and CD8 coreceptors to a single positive stage expressing only CD4 or CD8 in addition to the T cell receptor. They are then allowed to leave the thymus and enter the periphery via the lymphatics or venules of the circulatory system as mature T cells. (NCI/OSP)NCI
code
  • C19055
is rdfs:subClassOf of
is someValuesFrom of
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