About: Enediyne Antineoplastic Antibiotic     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Enediyne Antineoplastic Antibiotic
rdfs:subClassOf
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • Enediyne Antineoplastic Antibiotic
UMLS_CUI
  • C1516873
Legacy_Concept_Name
  • Enediyne_Antitumor_Antibiotic
FULL_SYN
  • Enediyne Antineoplastic AntibioticPTNCI
DEFINITION
  • An enediyne antineoplastic antibiotic isolated from Streptomyces bacterial species or derived synthetically. After cycloaromatization, the enediyne core of these antibiotics is converted to a benzene diradical intermediate that removes hydrogens from deoxyriboses along the minor groove of DNA, resulting in single- and double-strand breaks and apoptosis.NCI
code
  • C1927
is rdfs:subClassOf of
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