About: Esperamicin A1     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Esperamicin A1
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Antibiotic
Preferred_Name
  • Esperamicin A1
NSC_Code
  • 372668
UMLS_CUI
  • C0082481
CAS_Registry
  • 99674-26-7
Legacy_Concept_Name
  • Esperamicin_A1
CHEBI_ID
  • CHEBI:53273
FULL_SYN
  • Esperamicin A1PTNCI
  • Esperamicin A1SYDTPNSC0372668
DEFINITION
  • An enediyne antineoplastic antibiotic hybrid containing an anthranilate moiety. Esperamicin A1 is isolated from the bacterium Actinomadura verrucosospora. The anthranilate component of esperamicin A1 intercalates DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-stranded breaks in DNA and apoptosis. (NCI04)NCI
code
  • C1301
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