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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Topoisomerase II
rdfs:subClassOf
Semantic_Type
  • Enzyme
Preferred_Name
  • Topoisomerase II
UMLS_CUI
  • C0012863
Legacy_Concept_Name
  • Topoisomerase-II
FULL_SYN
  • Topoisomerase IIPTNCI
  • Topo IISYNCI
  • DNA Topoisomerase IISYNCI
DEFINITION
  • Topoisomerase II catalyzes relaxation of supercoiled DNA molecules, catenation, decatenation, knotting, and unknotting of circular DNA. The topoisomerase II reaction appears to involve crossing-over of two DNA segments. Human cells contain two topoisomerase II isozymes: alpha and beta from distinct genes. DNA topoisomerase II alpha is associated with the Pol II holoenzyme and is required for chromatin-dependent co-activation. Transcription results in superhelical tension; topoisomerase II relaxation activity is essential for productive RNA synthesis on nucleosomal DNA. (from OMIM 126430 and NCI)NCI
DesignNote
  • DNA topoisomerases I and II relax negative and positive supercoils; TOP1 breaks single DNA strands, TOP2 breaks duplex DNA.
code
  • C18434
sameAs
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