About: Tirapazamine

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Tirapazamine
equivalentClass	nodeID://b640669
Has_Target	DNA Topoisomerases, Type II DNA
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Tirapazamine
NSC_Code	130181
UMLS_CUI	C0208407
CAS_Registry	27314-97-2
In_Clinical_Trial_For	Head and Neck neoplasms; Non-small cell lung cancer; Rhabdomyosarcoma; Small cell lung cancer
FDA_UNII_Code	1UD32YR59G
Contributing_Source	FDA
ALT_DEFINITION	A drug that makes tumor cells more sensitive to radiation therapy.NCI-GLOSS
PDQ_Open_Trial_Search_ID	42158
PDQ_Closed_Trial_Search_ID	42158
Chemical_Formula	C7H6N4O2
Legacy_Concept_Name	Tirapazamine
FULL_SYN	TIRAPAZAMINEPTFDA1UD32YR59G TirapazaminePTNCI tirapazaminePTNCI-GLOSSCDR0000045427 3-Amino-1,2,4-benzotriazine-1,4-dioxideSNNCI SR4233CNNCI SR 4233CNNCI TirazoneBRNCI WIN 59075CNNCI
DEFINITION	A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. (NCI04)NCI
code	C1464
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0142901
is someValuesFrom of	nodeID://b657290 nodeID://b660214 nodeID://b660344 nodeID://b660518 nodeID://b660548 nodeID://b660551 nodeID://b663205 nodeID://b663674

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