About: Paroxetine Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Paroxetine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Paroxetine Hydrochloride
UMLS_CUI
  • C0771019
CAS_Registry
  • 78246-49-8
Accepted_Therapeutic_Use_For
  • Depression
FDA_UNII_Code
  • 3I3T11UD2S
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat depression and anxiety disorders. It is a type of selective serotonin reuptake inhibitor (SSRI).NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42793
PDQ_Closed_Trial_Search_ID
  • 42793
Chemical_Formula
  • C19H20FNO3.HCl
Legacy_Concept_Name
  • Paroxetine_Hydrochloride
FULL_SYN
  • paroxetine hydrochloridePTNCI-GLOSSCDR0000045553
  • Paroxetine HydrochloridePTNCI
  • PaxilPTNCI-GLOSSCDR0000410750
  • PaxilBRNCI
  • Paxil CRBRNCI
  • (-)-(3S,4R)-4-(p-Fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine HydrochlorideSNNCI
  • PAROXETINE HYDROCHLORIDE ANHYDROUSPTFDA3I3T11UD2S
DEFINITION
  • The hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness.NCI
code
  • C1837
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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