About: ETS Family Gene

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About: ETS Family Gene Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	ETS Family Gene
rdfs:subClassOf	Transcription Factor Gene nodeID://b669506 nodeID://b669507
Semantic_Type	Gene or Genome
Preferred_Name	ETS Family Gene
UMLS_CUI	C0812200
Legacy_Concept_Name	ETS_Family_Gene
FULL_SYN	ETS Family GenePTNCI ETS Family Proto-OncogenesSYNCI
Gene_Encodes_Product	ETS Family Protein
DEFINITION	The Ets family of transcription factors includes nuclear phosphoproteins that are involved in cell proliferation, differentiation and oncogenic transformation. The family is defined by a conserved DNA-binding domain (the ETS-DBD), which forms a highly conserved, winged, helix-turn-helix structural motif. As targets of the Ras-MAPK signaling pathway, Ets proteins function as critical nuclear integrators of ubiquitous signaling cascades. To direct signals to specific target genes, ETS proteins interact with other transcription factors that determine the binding specificity of ETS proteins to RAS-response elements in target genes.NCI
code	C18326
is rdfs:subClassOf of	ERG Gene ETV6 Gene FLI1 Gene ETS1 Gene ETS2 Gene ETV3 Gene ELK3 Gene ELK1 Gene SPI1 Gene ETV1 Gene ETV4 Gene ELF4 Gene ELK4 Gene ETV5 Gene FEV Gene SPIB Gene
is someValuesFrom of	nodeID://b669510

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