About: Transcription Factor Gene

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Attributes	Values
rdf:type	Class
rdfs:label	Transcription Factor Gene
rdfs:subClassOf	Transcription Regulation Gene nodeID://b720365 nodeID://b720366 nodeID://b720367
Semantic_Type	Gene or Genome
Preferred_Name	Transcription Factor Gene
UMLS_CUI	C0812327
Legacy_Concept_Name	Transcription_Factor_Gene
FULL_SYN	General Transcription Factor GeneSYNCI Transcription Factor GenePTNCI Proto-Oncogene, Transcription FactorSYNCI
Gene_Encodes_Product	Transcription Factor
DEFINITION	Genes that code for transcription factors.NCI
DesignNote	Initiation of transcription from eukaryotic protein-coding genes is a complex process requiring RNA polymerase II (Pol II) and a cadre of transcription factors. These factors can be divided into 2 classes on the basis of their function: the general factors that are required for transcription of all Pol II genes, and sequence-specific factors that are required for regulating expression. The general transcription factors and Pol II form a specific multiprotein complex near the transcription start site by interacting with core promoter elements. The most common core element is the TATA box, typically located 25-30 bp upstream of the transcriptional start site or initiator element. Sequence-specific transcription factors that bind to DNA-sequence elements located proximal and distal to the core promoter elements can dramatically enhance or repress transcription. (from OMIM 189962)
code	C20420
is rdfs:subClassOf of	TBX3 Gene YY1 Gene KLF5 Gene ZFPM2 Gene SOX10 Gene SPDEF Gene TBX21 Gene NFYA Gene ZNF423 Gene SOX11 Gene SREBF1 Gene ZEB1 Gene REL Gene LMO2 Gene TAL1 Gene SUPT5H Gene TFAP2A Gene MAX Gene SP1 Gene AFF3 Gene SMAD2 Gene MSC Gene TAL2 Gene TCF7L2 Gene MYB Gene TCF21 Gene NFE2L2 Gene SOX2 Gene OLIG2 Gene TOX3 Gene MITF Gene KLF4 Gene SOX6 Gene TBX1 Gene ZEB2 Gene SIM1 Gene SOX3 Gene SOX9 Gene TRPS1 Gene ZIC2 Gene ZIC3 Gene ZIC4 Gene SOX18 Gene LEF1 Gene MYT1L Gene ZFPM1 Gene KLF1 Gene PLAGL2 Gene SNAI1 Gene LMO1 Gene TP63 Gene TBX5 Gene MEF2A Gene MEF2B Gene MEF2C Gene MEF2D Gene NFE2 Gene NFAT5 Gene NFATC1 Gene NFATC3 Gene NFATC4 Gene NFKB1 Gene MYOG Gene TFDP1 Gene SOX8 Gene KLF6 Gene MLF1 Gene TCF12 Gene ZNF384 Gene ZNF521 Gene TCF7 Gene PRRX1 Gene SP3 Gene LHX4 Gene ZNF350 Gene NEUROD1 Gene FOXO6 Gene FOXM1 Gene FOXA1 Gene TFCP2 Gene MLXIPL Gene FOXA3 Gene HAND2 Gene

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