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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Rofecoxib
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Rofecoxib
NSC_Code
  • 720256
UMLS_CUI
  • C0762662
CAS_Registry
  • 162011-90-7
Accepted_Therapeutic_Use_For
  • Pain; dysmenorrhea; osteoarthritis; rheumatoid arthritis
In_Clinical_Trial_For
  • Colorectal cancer; brainstem glioma
FDA_UNII_Code
  • 0QTW8Z7MCR
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that was being used for pain relief and was being studied for its ability to prevent cancer and to prevent the growth of new blood vessels that tumors need to grow. It is a type of nonsteroidal anti-inflammatory drug and a type of antiangiogenesis agent. Rofecoxib was taken off the market in the U.S. because of safety concerns.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38568
PDQ_Closed_Trial_Search_ID
  • 38568
Chemical_Formula
  • C17H14O4S
Legacy_Concept_Name
  • Rofecoxib
CHEBI_ID
  • CHEBI:8887
FULL_SYN
  • 4-[4'-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanoneSNNCI
  • RofecoxibPTDCP31782
  • VioxxPTNCI-GLOSSCDR0000413735
  • VioxxBRNCI
  • MK 966CNNCI
  • ROFECOXIBPTFDA0QTW8Z7MCR
  • RofecoxibPTNCI
  • rofecoxibPTNCI-GLOSSCDR0000045083
DEFINITION
  • A synthetic, nonsteroidal derivative of phenyl-furanone with antiinflammatory, antipyretic and analgesic properties and potential antineoplastic properties. Rofecoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2. (NCI04)NCI
code
  • C1832
sameAs
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