About: Mitomycin

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Attributes	Values
rdf:type	Class
rdfs:label	Mitomycin
rdfs:subClassOf	Mitomycins
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Antibiotic Organic Chemical
Preferred_Name	Mitomycin
NSC_Code	26980
UMLS_CUI	C0002475
CAS_Registry	50-07-7
Accepted_Therapeutic_Use_For	Gastric Carcinoma Pancreatic Adenocarcinoma
FDA_UNII_Code	50SG953SK6
Contributing_Source	FDA
PDQ_Open_Trial_Search_ID	42674
PDQ_Closed_Trial_Search_ID	42674
Chemical_Formula	C15H18N4O5
Legacy_Concept_Name	Mitomycin_C
CHEBI_ID	CHEBI:27504
FULL_SYN	MitozytrexBRNCI Mitomycin CSYNCI Mitomycin-CSYNCI Mitomycin-XSYNCI MitomycinPTDCP00341 Mitomycine CSYNCI Mito-CSYDTPNSC0026980 MITOABNCI MITO-CABNCI MITOMYCINPTFDA50SG953SK6 Mitocin-CSYDTPNSC0026980 MitocinFBNCI MitolemFBNCI MitosolBRNCI AmetycineSYDTPNSC0026980 MutamycinSYDTPNSC0026980 (1aS,8S,8aR,8bS)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dioneSNNCI MITOMYCIN CSYDTPNSC0134727 Mitocin-CFBNCI AmetycineFBNCI [1aS-(1a alpha,8beta,8a alpha,8b alpha)]-6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dioneSNNCI MutamycinBRNCI MitomycinPTNCI NCI-C04706CNNCI MitomycinSYNCITCGA Mito-MedacFBNCI Mitomycin CSYDTPNSC0026980 MutamycineFBNCI
DEFINITION	A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. (NCI04)NCI
code	C1820
sameAs	MITOMYCIN MITOMYCIN
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0013948
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