About: Shark Cartilage Extract AE-941     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Shark Cartilage Extract AE-941
equivalentClass
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Shark Cartilage Extract AE-941
NSC_Code
  • 706456
UMLS_CUI
  • C1963096
CAS_Registry
  • 305838-77-1
In_Clinical_Trial_For
  • Unresectable Stage IIA or IIIB Non-Small Cell Lung Cancer; Advanced Solid Tumors; Metastatic Renal Cell Carcinoma Refractory to Immunotherapy; Early Relapse or Refractory Multiple Myeloma.
ALT_DEFINITION
  • A substance made from shark cartilage that is being studied for its ability to prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42021
PDQ_Closed_Trial_Search_ID
  • 42021
Legacy_Concept_Name
  • Neovastat
FULL_SYN
  • [AElig]-941CNNCI
  • NeovastatPTDCP31675
  • AE-941PTNCI-GLOSSCDR0000045103
  • AE-941CNNCI
  • Shark Cartilage Extract AE-941PTNCI
  • NeovastatBRNCI
DEFINITION
  • A multifunctional antiangiogenic agent derived from shark cartilage with potential antineoplastic activity. Shark cartilage extract AE-941 competitively inhibits the binding of pro-angiogenic vascular endothelial growth factor (VEGF) to its cellular receptor, thereby inhibiting endothelial cell proliferation. This agent also inhibits matrix metalloproteinases (MMPs), stimulates tissue plasminogen activator (tPA), and activates caspase-mediated apoptotic pathways in endothelial cells.NCI
code
  • C1798
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