About: Protein Kinase C     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Protein Kinase C
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • Protein Kinase C
UMLS_CUI
  • C0033634
ALT_DEFINITION
  • An enzyme found throughout the body's tissues and organs. Several forms of PKC are involved in many cellular functions. PKC is being studied in the treatment of cancer.NCI-GLOSS
Legacy_Concept_Name
  • Protein_Kinase-C
FULL_SYN
  • EC 2.7.11.13SYNCI
  • PKCPTNCI-GLOSSCDR0000403142
  • PKCABNCI
  • Protein Kinase CPTNCI
  • protein kinase CPTNCI-GLOSSCDR0000318824
DEFINITION
  • A family of serine/threonine protein kinases that have a structurally conserved catalytic subunit and a regulatory subunit that are connected by a hinge domain.NCI
DesignNote
  • There are 3 classes of protein kinase C isozymes based on the molecular requirement for activation. Conventional isozymes need calcium ions, diacylglycerol and phospholipids for activation. Novel isozymes require diacylglycerol and are not regulated by calcium ions, while atypical isozymes require neither diacylglycerol nor calcium ions.
code
  • C17017
sameAs
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