About: 7-Hydroxystaurosporine

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Attributes	Values
rdf:type	Class
rdfs:label	7-Hydroxystaurosporine
equivalentClass	nodeID://b641417
Has_Target	Proto-Oncogene Proteins c-akt Protein Kinase C RAC-Alpha Serine/Threonine Kinase Cyclin-Dependent Kinases Serine/Threonine-Protein Kinase Chk1
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	7-Hydroxystaurosporine
NSC_Code	638850
UMLS_CUI	C0077681
CAS_Registry	112953-11-4
In_Clinical_Trial_For	Leukemia; Lymphoma; Ovarian epithelial, primary peritoneal, or fallopian tube cancer; Unspecified solid tumors
FDA_UNII_Code	7BU5H4V94A
Contributing_Source	FDA
ALT_DEFINITION	An anticancer drug that belongs to the family of drugs called staurosporine analogues.NCI-GLOSS
PDQ_Open_Trial_Search_ID	42305
PDQ_Closed_Trial_Search_ID	42305
Chemical_Formula	C28H26N4O4
Legacy_Concept_Name	_7-Hydroxystaurosporine
FULL_SYN	7-HydroxystaurosporinePTNCI 7-Hydroxy-staurosporineSNNCI UCN-01SYDTPNSC0638850 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo[a, g]cyclonona[cde] Trinden-1-one, 2,3,9,10,11, 12-hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino)SNNCI 2,3,9,10,11,12-Hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino)-8,12-epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)triinden-1-onePTDCP30071 7-HYDROXYSTAUROSPORINEPTFDA7BU5H4V94A UCN-01PTNCI-GLOSSCDR0000045447 7-HydroxystaurosporineSYDTPNSC0638850 UCN-01CNNCI (+)-UCN-01SYDTPNSC0638850
DEFINITION	A synthetic derivative of staurosporine with antineoplastic activity. 7-hydroxystaurosporine inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases. This agent arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis. (NCI04)NCI
code	C1271
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0154702
is someValuesFrom of	nodeID://b657343 nodeID://b660566 nodeID://b664409 nodeID://b673813 nodeID://b674045 nodeID://b674153 nodeID://b676726 nodeID://b684398 nodeID://b703970 nodeID://b720085

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