About: Monoclonal Antibody Ch14.18

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About: Monoclonal Antibody Ch14.18 Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Monoclonal Antibody Ch14.18
rdfs:subClassOf	Antibodies, Monoclonal nodeID://b693635 nodeID://b693636 nodeID://b693637 nodeID://b693638
Has_Target	Ganglioside GD2
Semantic_Type	Amino Acid, Peptide, or Protein Immunologic Factor
Preferred_Name	Monoclonal Antibody Ch14.18
NSC_Code	623408
UMLS_CUI	C0281581
In_Clinical_Trial_For	Neuroblastoma
ALT_DEFINITION	A substance being studied in the treatment of cancer. It binds to a molecule called GD2, which is found in greater than normal amounts on some types of cancer cells. This helps cells of the immune system kill the cancer cells. It is a type of monoclonal antibody.NCI-GLOSS
PDQ_Open_Trial_Search_ID	42042
PDQ_Closed_Trial_Search_ID	42042
Legacy_Concept_Name	Monoclonal_Antibody_Ch14_18
FULL_SYN	MoAb Ch14.18SYNCI MOAB Ch14.18PTNCI-GLOSSCDR0000665426 monoclonal antibody Ch14.18PTNCI-GLOSSCDR0000665424 Ch14.18 Monoclonal AntibodySYNCI Monoclonal Antibody Ch14.18PTNCI Ch14.18PTNCI-GLOSSCDR0000665425 Ch14.18SYNCI
DEFINITION	A chimeric mouse/human monoclonal antibody with potential antineoplastic activity. Monoclonal antibody Ch14.18 binds to the ganglioside GD2 and induces antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity against GD2-expressing tumor cells. GD2 is overexpressed in malignant melanoma, neuroblastoma, osteosarcoma, and small cell carcinoma of the lung. (NCI04)NCI
code	C1570
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0291425
is someValuesFrom of	nodeID://b683737 nodeID://b683769 nodeID://b683772 nodeID://b684443 nodeID://b684445 nodeID://b693604

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