About: Ganglioside GD2     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ganglioside GD2
rdfs:subClassOf
Semantic_Type
  • Lipid
  • Immunologic Factor
Preferred_Name
  • Ganglioside GD2
UMLS_CUI
  • C0061104
CAS_Registry
  • 65988-71-8
PDQ_Open_Trial_Search_ID
  • 42295
PDQ_Closed_Trial_Search_ID
  • 42295
Legacy_Concept_Name
  • Ganglioside_GD2
FULL_SYN
  • GalNAc(beta 1->4)-[NeuAc(alpha 2->8)NeuAc(alpha 2->3)]Gal(beta 1->4)GlcCerSNNCI
  • Ganglioside GD2PTNCI
  • GD2 gangliosideSYNCI
DEFINITION
  • A cell surface antigen expressed on all tumors of neuroectodermal origin, including melanoma, neuroblastomas, sarcoma, astrocytomas, and small cell lung cancer. GD2, an O-acetylated disialoganglioside, belongs to the group of glycosphingolipids that are widely expressed in many tissues and organs in vertebrates and have been suggested to be involved in the regulation of development and differentiation as recognition molecules or signal modulators. Due to its high level of expression in neuroblastoma, GD2 has the potential to be used as a component of anti-neuroblastoma vaccines, in addition to being used in polyvalent anti-melanoma vaccines.NCI
code
  • C1110
http://linked.open...y/mesh/hasConcept
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