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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Peplomycin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Antibiotic
Preferred_Name
  • Peplomycin
NSC_Code
  • 276382
UMLS_CUI
  • C0135981
CAS_Registry
  • 68247-85-8
FDA_UNII_Code
  • 56H9L80NIZ
Contributing_Source
  • FDA
ALT_DEFINITION
  • An antineoplastic agent derived from BLEOMYCIN.MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 39552
PDQ_Closed_Trial_Search_ID
  • 39552
Chemical_Formula
  • C61H88N18O21S2
Legacy_Concept_Name
  • Peplomycin
FULL_SYN
  • PepleomycinSYNCI
  • (S)-n1-[3-[(1-phenylethyl)amino]propyl]bleomycinamideSNNCI
  • PEPABNCI
  • n1-[3[[(S)-alpha-methylbenzyl]amino]propyl]bleomycinamideSNNCI
  • PEPLOMYCINPTFDA56H9L80NIZ
  • PEPLEOMYCINSYDTPNSC0276382
  • PeplomycinPTNCI
DEFINITION
  • A semisynthetic analog of Bleomycin, a mixture of several basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA. This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity. (NCI04)NCI
code
  • C1399
sameAs
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