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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Trimetrexate
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Trimetrexate
NSC_Code
  • 249008
UMLS_CUI
  • C0085176
CAS_Registry
  • 52128-35-5
FDA_UNII_Code
  • UPN4ITI8T4
Contributing_Source
  • FDA
ALT_DEFINITION
  • A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against Pneumocystis carinii pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect.MSH2002_06_01
Chemical_Formula
  • C19H23N5O3
Legacy_Concept_Name
  • Trimetrexate
FULL_SYN
  • TRIMETREXATEPTFDAUPN4ITI8T4
  • TrimetrexateSYDTPNSC0352122
  • TrimetrexatePTNCI
  • TMQABNCI
  • 5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediamineSNNCI
  • CI-898CNNCI
  • 2,4-Quinazolinediamine, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-SYDTPNSC0249008
  • TrimexateSYNCI
DEFINITION
  • A methotrexate derivative with potential antineoplastic activity. Trimetrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate also exhibits antiviral activity. (NCI04)NCI
code
  • C1314
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Free_Acid_Or_Base_Form of
is sameAs of
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