About: Trimetrexate Glucuronate

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About: Trimetrexate Glucuronate Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Trimetrexate Glucuronate
rdfs:subClassOf	Dihydrofolate Reductase Inhibitor
Has_Free_Acid_Or_Base_Form	TRIMETREXATE
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Trimetrexate Glucuronate
NSC_Code	352122
UMLS_CUI	C0077209
CAS_Registry	82952-64-5
Accepted_Therapeutic_Use_For	Head and neck cancer; Metastatic colorectal adenocarcinoma; Non-small cell lung cancer; Osteogenic sarcoma; Pancreatic adenocarcinoma; Pneumocystitis carinii pneumonia
In_Clinical_Trial_For	Acute lymphoblastic leukemia; Non-Hodgkins lymphoma; Osteosarcoma
FDA_UNII_Code	L137U4A79K
Contributing_Source	FDA
ALT_DEFINITION	A drug that belongs to the family of drugs called antimetabolites. It is used in the treatment of pneumocystis carinii pneumonia and is being studied in the treatment of cancer.NCI-GLOSS
PDQ_Open_Trial_Search_ID	39764
PDQ_Closed_Trial_Search_ID	39764
Chemical_Formula	C19H23N5O3.C6H10O7
Legacy_Concept_Name	Trimetrexate_Glucuronate
FULL_SYN	trimetrexate glucuronatePTNCI-GLOSSCDR0000045259 Trimetrexate GlucuronatePTNCI TRIMETREXATE GLUCURONATEPTFDAL137U4A79K TRIMETREXATE GLUCURONATESYDTPNSC0352122 NeutrexinBRNCI 2,4-Diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline mono-D-glucuronateSNNCI
DEFINITION	A lipid soluble methotrexate derivative with potential antineoplastic activity. Trimetrexate glucuronate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate glucuronate also exhibits antiviral activity. (NCI04)NCI
code	C1265
sameAs	TRIMETREXATE GLUCURONATE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0158006
is someValuesFrom of	nodeID://b660563 nodeID://b666004 nodeID://b671233 nodeID://b674042 nodeID://b674150 nodeID://b686734 nodeID://b702263
is Has_Salt_Form of	TRIMETREXATE
is sameAs of	TRIMETREXATE GLUCURONATE TRIMETREXATE GLUCURONATE

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