About: Pegylated Liposomal Mitomycin C Lipid-based Prodrug

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Attributes	Values
rdf:type	Class
rdfs:label	Pegylated Liposomal Mitomycin C Lipid-based Prodrug
rdfs:subClassOf	Mitomycins
Semantic_Type	Antibiotic Organic Chemical
Preferred_Name	Pegylated Liposomal Mitomycin C Lipid-based Prodrug
NCI_META_CUI	CL438127
PDQ_Open_Trial_Search_ID	741900
PDQ_Closed_Trial_Search_ID	741900
FULL_SYN	PL-MLPABNCI PromitilFBNCI Pegylated Liposomal Mitomycin C Lipid-based ProdrugPTNCI
DEFINITION	A pegylated liposomal formulation comprised of a lipophilic prodrug of the antineoplastic antibiotic mitomycin C containing a cleavable disulfide bond (PL-MLP), with potential antineoplastic activity. Upon administration of the pegylated liposomal mitomycin C lipid-based prodrug, the MLP moiety becomes activated upon thiolysis at the tumor site, thereby releasing mitomycin C. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. The thiolytic environment and upregulated expression of thioredoxins at the tumor site allow for the activation and release of mitomycin C. This prodrug formulation allows for greater circulation time, less systemic toxicity and increased accumulation of mitomycin C at the tumor site.NCI
code	C103276

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